4) Monsanto P, Almeida N, Lrias C, Pina JE, Sofia C. (2013) Evaluation of MELD score and Maddrey discriminant function for mortality prediction in patients with alcoholic hepatitis. It is most commonly used as international normalized ratio (INR), which is prothrombin time/control time. Maddreys discriminant function for alcoholic hepatitis suggests which patients with alcoholic hepatitis may have a poor prognosis and benefit from steroid administration. In severe cases, corticosteroid therapy (is recommended) has shown an improvement in short term survival. It is calculated as follows: DF = (4.6 x [prothrombin time (sec) - control prothrombin time (sec)]) + (serum bilirubin mg/dL) Patients with a score 32 or higher have a high risk of short-term mortality and . The discriminant function applied in stratifying AH patients is: DF = 4.6 x (Prothrombin time - Control time) + Bilirubin in mg/dL 519-751-5544. Where. Acute onset of jaundice is the only clinical sign or symptom required for the diagnosis of alcoholic hepatitis.7,10 However, other nonspecific signs and symptoms (Table 21,11,12 and Figure 1) can support the diagnosis of alcoholic hepatitis and suggest underlying chronic alcohol-associated liver disease. The only criticism given to the model relates to the usage of the variables for mortality risk stratification but being able to account for in time progression thus cannot really be used for proper monitoring. Maddrey discriminant function and MELD scores) can be used to assess severity and short-term prognosis and guide management. By using this form you agree with the storage and handling of your data by this website. Complete abstinence from alcohol is advised for all patients and is considered the most effective intervention. Signed in as Close. Healthline Media does not provide medical advice, diagnosis, or treatment. of Alcoholic Hepatitis, Lille Model Scoring in Severe Alcoholic Hepatitis, MELD Score (Model Read our. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Brantford General Hospital. Treatment for mild or moderate alcoholic hepatitis includes: An MDF score equal to or greater than 32 means you likely have severe alcoholic hepatitis. Evaluation of MELD score and Maddrey discriminant function for mortality prediction in patients with alcoholic hepatitis. Up to a certain point, you may be able to reverse damage to your liver over time if you stop drinking. Everything You Want to Know About Hepatitis C, Common Viruses May Be Behind Outbreak of Mysterious Hepatitis Cases in Children, WHO Says at Least 650 Children Have Developed Mysterious Hepatitis. DOI: Stickel F, et al. control time It may even lead to death without aggressive management. maddrey discriminant function mdcalcapartments for rent in kitimat, bc. "Corticosteroid therapy of alcoholic hepatitis". discriminant function Any algorithm or assessment tool to evaluate disease severity or guide clinical or administrative decisions in health care. World J Gastroenterol; 12(25):4020-5. Liver biopsy is necessary only if the diagnosis is unclear and accurate diagnosis would impact management.7,10. Below the form you can find more information on the discriminant function and its usage. Alcoholic hepatitis however is a condition that can be treated successfully with medication such as prednisolone but only following discontinuation of alcohol and monitoring of the patient through assessments such as the CIWA-Ar alcohol withdrawal questionnaire. Discriminant function = 4.6 x (PTa - PTc) + Bili. Shasthry SM, et al. Parenteral nutrition is given by vein. Dr. Maddrey is professor of internal medicine at The University of Texas Southwestern Medical Center at Dallas. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Interpretation. ( serum bilirubin in mg/dl Discriminant result >32 is associated with severe disease and a 1 month mortality >50%. This is a health tool also known as the Maddrey's discriminant function (DF) that predicts the outcome, mortality risk in one month, in patients suffering from alcohol-related hepatitis and also identifies cases in which steroid therapy is recommended. Heavy alcohol intake is a controversial subject with sources citing it starts at daily ingestion of more than 10 20 g for women and 20 40 g for men. Steps on how to print your input & results: 1. It also increases the risk of liver cancer and kills liver cells. not US) divide bilirubin value by 17. Also often given as the INR (international normalized ratio) result directly. Please be cautious in utilization of any information that may be identifiable and refrain from using on this site. Mdcalc.com is a Health website . 2) Soultati AS, Dourakis SP, Alexopoulou A, Deutsch M, Vasilieva L, Archimandritis AJ. Typically, about 90 to 100 percent of people are still living 3 months after receiving the diagnosis. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. Copyright 2022 by the American Academy of Family Physicians. This is a health tool also known as the Maddreys discriminant function (DF) that predicts the outcome, mortality risk in one month, in patients suffering from alcohol-related hepatitis and also identifies cases in which steroid therapy is recommended. Fifty-five patients with alcoholic hepatitis were studied in a 28- to 32-day randomized double blind treatment trial comparing prednisolone (40 mg per day) with placebo therapy. In time, excessive alcoholism leads to hepatic symptoms and affectation of the liver function. You have left! Normal range is between 11 to 13.5 seconds in patients that are not under blood thinning medication such as warfarin. (n.d.). This medical diagnostic article is a stub. Twitter Facebook Pinterest : Your doctor will likely also monitor you for other complications, such as gastrointestinal bleeding, pancreatitis, or kidney failure. Alcoholic hepatitis is a clinical syndrome characterized by acute-onset jaundice and liver enzyme abnormalities in the setting of long-term heavy alcohol use. Close monitoring for inflammation and organ failure is crucial throughout hospitalization. INSTRUCTIONS Use in patients 12 years old. Up to 35 percent of heavy drinkers develop this condition. Gastroenterology. Alcoholic hepatitis can quickly become severe. Perform imaging tests like an ultrasound and a liver biopsy if needed. It stars Vijay, Sonia Agarwal, and Rakshitha in the lead roles while Vadivelu, Pasupathy, Seetha . Alcoholic liver disease: Prognosis. Predicts short term prognosis in patients with alcoholic hepatitis (AH) and helps prioritize steroid therapy. Its one of the tests that measures how long it takes your blood to clot. Perhaps they might use the middle of the PT reference range for this. The Maddrey Score (known as discriminant function) can be used to predict short term prognosis in patients with alcoholic hepatitis (AH) and helps prioritize corticosteroid therapy. This is also known as Maddreys discriminant function and is based on prothrombin time, control time and bilirubin value. Where. (2013). Interpretation:. The incidence of alcoholic hepatitis is difficult to estimate because of inconsistency in diagnosis of the disease and overlap with concurrent, more easily diagnosed liver diseases, such as hepatitis C.1,2 However, hospital admissions for alcoholic hepatitis are on the rise in the United States, accounting for 0.83% of all admissions in 2010.1 Risk factors for the development of the disease include prolonged and heavy alcohol use, younger age, female sex, genetic susceptibility, higher body mass index, and comorbid liver disease.1,35 Overall and in-hospital mortality are high for severe alcoholic hepatitis, with a 28-day mortality rate of 16% to 30% and a one-year mortality rate of 56%.6 The presence of underlying cirrhosis and continued alcohol use negatively impact long-term prognosis.4,79, Because of historical variability in the diagnosis of alcoholic hepatitis, the National Institute on Alcohol Abuse and Alcoholism developed a consensus statement for diagnosing the disease (Table 1).1,7,10 The diagnosis is primarily clinical and must include acute-onset jaundice, specific laboratory abnormalities, and characteristic history of alcohol use (i.e., long-term consumption of roughly three standard drinks daily for women and four standard drinks daily for men). Privacy Policy. Agencia de Talentos deportivos. In addition, stratification should be based on severity as assessed by: Maddrey discriminant function >32, assuming a control prothrombin time of 12 seconds; and model for end stage liver Calculator: Hepatitis discriminant function for estimating disease severity in adults with alcoholic hepatitis 1 vote 2 votes 3 votes Remove votes. Site is running on IP address 172.67.194.4, host name 172.67.194.4 ( United States ) ping response time 17ms Good ping. Close. It is a tool used by healthcare providers to determine the appropriate type of care for a patient who has a specific type of liver damage called alcoholic cirrhosis . High rates of concomitant infections, systemic inflammation, and multiorgan failure lead to significant morbidity and mortality. Model for end-stage liver disease score versus Maddrey discriminant function score in assessing short-term outcome in alcoholic hepatitis. Alcoholic hepatitis is a type of alcohol-related liver disease. To view Dr. W. Ray Kim's publications, visit PubMed Are you Dr. W. Ray Kim? World J Gastroenterol. Presence of the characteristic alcohol use history is an important component of the clinical diagnosis, and patient reluctance to disclose alcohol use is a significant issue.13 Validated screening tools (Table 310,1417) and collateral history from family members can aid in identifying high-risk alcohol use.1 The Alcohol Use Disorders Identification Test-Concise screening questionnaire is a more targeted screening tool for identifying alcohol misuse than the CAGE (cut down, annoyed, guilty, eye-opener) questionnaire.14. Of these, the Maddrey Discriminant Function (MDF) is the simplest. Privacy Policy. Creating an account is free and takes less than 1 minute. following a 28- to 32-day randomized double blind treatment trial study (prednisolone 40 mg vs placebo) on 55 patients with alcoholic hepatitis. J Gastroenterol Hepatol. Please sign in to leave feedback. Mild alcoholic hepatitis can last for years. Otherwise, the damage to your liver will continue to get worse and become permanent. Maddrey Discriminant Function: Severe disease 32 Glasgow Alcoholic Hepatitis Score: Severe disease 9 MELD: Severe disease 21 Lille Score: Predictor of steroid response after 7 days of therapy: 0.16; complete responder 0.16-0.56; partial responder 0.56; null responder ABIC Score: Predictor of 90 day mortality: 6.71; low risk Scores range from 6 to 40, with higher scores correlating with increased severity of liver dysfunction and higher three-month mortality. 2. Content is updated monthly with systematic literature reviews and conferences. Background/aims: Maddrey discriminant function (DF) is the traditional model for evaluating the severity and prognosis in alcoholic hepatitis (AH). Hepatogastroenterology. In December 2006 the allocation of livers from deceased donors in Germany and several other Eurotransplant countries was reset. The main limitation of the study is linked to the fact that it only offers short term prognosis and cannot account for progression of the disease in time. Previously, he directed the liver unit at The Johns Hopkins University School of Medicine and was chairman of the Department of Medicine at Jefferson Medical College.1, https://www.mdcalc.com/maddreys-discriminant-function-alcoholic-hepatitis, In a meta-analysis of 4 controlled trials, we found corticosteroid use to reduce risk of death within 28 days of treatment, but not in the following 6 months. Discriminant function = 4.6 x (PTa - PTc) + Bili. "Corticosteroid therapy of alcoholic hepatitis", "Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis", "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial", "Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data", https://en.wikipedia.org/w/index.php?title=Modified_Maddrey%27s_discriminant_function&oldid=1123786057, Wikipedia articles needing clarification from March 2020, Articles with unsourced statements from November 2022, Creative Commons Attribution-ShareAlike License 3.0, evaluate severity of alcoholic hepatitis, This page was last edited on 25 November 2022, at 17:53. Gastroenterology; 75(2):193-9. [4] Corticosteroid therapy or pentoxifylline have been used with mixed results for patients whose increased mortality is indicated with a value greater than 32.[5]. Provide nutritional support for patients with alcoholic hepatitis, with a daily energy intake of 35 to 40 kcal per kg of body weight and a daily protein intake of 1.2 to 1.5 g per kg of body weight. See encephalopathy grades in Evidence > Facts & Figures, Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. how to apply bronzer and highlighter; causes of religious intolerance pdf; concerts in glasgow 2022; valley view spartans football roster; nutrition global health issue; Kadian M, Kakkar R, Dhar M, Kaushik RM. Discriminant Function = 4.6 * (Pt's PT - Control PT) + TBili I'm guessing the Control PT would be a Prothrombin time of a normal patient. Maddrey score = 4.6 X (prolongation of prothrombin time above control in seconds) + Total bilirubin in mg/dl To calculate Maddrey discriminant function using SI units - micromol/l (i.e. Do Not Copy, Distribute or otherwise Disseminate without express permission. All Maddrey score results above 32 are indicative of a poor prognosis with 35-45% mortality risk within first month. Maddrey's discriminant function (DF) is the traditional model for evaluating the severity and prognosis in alcoholic hepatitis and evaluates the efficacy of using alcoholic hepatitis steroid treatment. About 55 to 65 percent of people with this score are still living 3 months after diagnosis. Only 1 Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. This stratification method was designed in 1978 by Maddrey et al. The MELD was updated in January 2016 and now includes serum sodium level. Alcohol use disorders. Laboratory findings that are diagnostic for alcoholic hepatitis or characteristic of alcohol-associated liver disease are outlined in Table 21,11,12; deviation from the specified diagnostic pattern should prompt consideration of alternative diagnoses. Cirrhosis develops in 50% of chronic Alcoholic Hepatitis patients Outbreaks of HIV and hepatitis have convinced officials in small towns across the United States that needle exchange programs are necessary. Laboratory-based prognostic scores, including Maddrey Discriminant Function and the Model for End-Stage Liver Disease, help determine disease severity and treatment options. It now includes serum sodium level. These are some of the conditions that can develop: Alcoholic hepatitis can be treated successfully with corticosteroid medication such as prednisolone but it is essential that the patient discontinues alcohol and is regularly monitored for alcohol withdrawal symptoms, with assessments such as CIWA-Ar. Consistency across guidelines and cohort studies, Guidelines based on RCTs and meta-analysis of RCTs, Long-term consumption of alcohol: > 40 g (roughly 3 standard drinks) daily for women or > 60 g (roughly 4 standard drinks) daily for men for 6 months, with < 60 days of abstinence before onset of jaundice, AST > 50 U per L (0.83 kat per L), AST/ALT ratio > 1.5, and both AST and ALT < 400 U per L (6.68 kat per L), Total bilirubin > 3 mg per dL (51.31 mol per L), Possible ischemic hepatitis (suggested by severe upper gastrointestinal tract bleed, hypotension, cocaine use within seven days of symptom onset), Possible metabolic liver disease (Wilson disease, alpha, Possible drug-induced liver disease (use of offending drug within 30 days of jaundice onset), Uncertain alcohol use assessment (patient denies excessive alcohol use), Atypical laboratory findings (AST < 50 U per L or > 400 U per L, AST/ALT ratio < 1.5, antinuclear antibodies > 1: 160, or antismooth muscle antibodies > 1: 80), If diagnostic confirmation would change management in the presence of confounding factors, perform liver biopsy, Immediate, unlimited access to all AFP content, Immediate, unlimited access to this issue's content, Immediate, unlimited access to just this article. A MELD score of 18 and higher is associated with a poorer outlook. (2006) Predicting utility of a model for end stage liver disease in alcoholic liver disease. However, MELD has also been used for this purpose. Alcoholic liver disease. J Gastroenterol Hepatol; 29(3):581-8. The Maddrey tool helps your doctor quickly recognize the severity of alcoholic hepatitis. Supportive management includes nutritional support, monitoring for alcohol withdrawal syndrome [clarification needed] The subject's Maddrey DF score is determined by blood analysis. The Willett, Paris. Nutritional support with enteral feeding, also called tube feeding. It can be used to determine the required, In the U.S., hepatitis C (HCV) infection is the leading cause of cirrhosis and liver cancer. PTc: Normal ProTime (PT) in seconds (typically 11-13 s) Bili: Serum Bilirubin in mg/dl. Maddrey's discriminant function for alcoholic hepatitis suggests which patients with alcoholic hepatitis may have a poor prognosis and benefit from steroid administration. Liver conditions caused by prolonged heavy alcohol intake include: Heavy alcohol intake definition is still arguable, with some sources stating it at daily ingestion of more than 10 20g for women and 20 40g for men. The numeric result provided after the discriminant function is calculated is interpreted (by a clinician) according to the following rule. Monsanto P, Almeida N, Lrias C, Pina JE, Sofia C. Evaluation of MELD score and Maddrey discriminant function for mortality prediction in patients with alcoholic hepatitis. The bilirubin value reflects the metabolic function of the liver and is usually higher than normal in cases of alcoholic liver disease. {\displaystyle \left(4.6\times \left({\hbox{prothrombin time}}-{\hbox{control time}}\right)\right)+{\hbox{serum bilirubin in mg/dl}}} Dr. You still drink alcohol. See OPTN's announcement. Evaluate the response to corticosteroid therapy in alcoholic hepatitis using the Lille score at day 7 of treatment. DOI: Monsanto P, et al. NICE suggest the use Maddrey's discriminant function (DF) to determine treatment in people with severe acute alcohol related hepatitis (1) it is 4.6 x [prothrombin time - control time (seconds)] + bilirubin in mg/dl. Pathophysiology and management of alcoholic liver disease. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. The three variables accounted for in the Maddrey score are explained in the table below: The discriminant function is calculated based on the following formula: DF = 4.6 x (Prothrombin time - Control time) + Bilirubin in mg/dL If bilirubin is provided in mol/L, the equation can be adapted: Maddrey's discriminant function (DF) is the traditional model for evaluating the severity and prognosis in alcoholic hepatitis and evaluates the efficacy of using alcoholic hepatitis steroid treatment. Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr. Corticosteroid therapy of alcoholic hepatitis. Privacy Policy. Corticosteroids are recommended for severe alcoholic hepatitis. official version of the modified score here. doi: 10.1053/j.gastro.2018.05.011. Maddrey discriminant function [DF] score 32 ()( B1B6)() Wei 14, May 2018 00:30 5 13, 2018 BlogThis! This tool was created by Dr. Willis Maddrey. Background/aims: Maddrey discriminant function (DF) is the traditional model for evaluating the severity and prognosis in alcoholic hepatitis (AH). This uses your bilirubin, creatinine, and international normalized ratio (INR) result, which is based on your prothrombin time. 1978; 75(2):193-9. Stepwise discriminant analysis of laboratory factors associated with exitus showed that prolongation of prothrombin time and elevation of serum bilirubin have an independent predictive value. It helps your doctor further evaluate your condition. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. For convenience, the user can choose the measurement system either SI or US therefore can input serum bilirubin in either mg/dL or mol/L. (2017). official version of the modified score here. MDCalc - Medical calculators, equations, scores, and guidelines Creatinine Clearance (Cockcroft-Gault Equation) Calculates CrCl according to the Cockcroft-Gault equation. The two formulas adapted for the measurements units are: DF = 4.6 x (prothrombin time - control time) + bilirubin in mg/dL, DF = 4.6 x (prothrombin time - control time) + (bilirubin in mol/L)/17.1. Learn about symptoms, causes. Of 31 placebo-treated patients, 4 died during the trial interval and 2 died within 5 days of trial completion. The presence of underlying cirrhosis and continued alcohol use negatively impact long-term prognosis. The MELD Score (Model For End-Stage Liver Disease) (12 and older) quantifies end-stage liver disease for transplant planning. All rights reserved. It also predicts the likelihood of survival within the next month or several months. Early, aggressive management can improve the outlook for people with this condition, especially if you have severe alcoholic hepatitis. (n.d.). Gastroenterology. The formula to calculate the score is as follows: Indicates the clotting performance and indirectly liver function. Patients with severe alcoholic hepatitis (Maddrey's discriminant function, [greater than or equal to] 32; or MELD score, [greater than or equal to] 21: or GAHS, [greater than or equal to] 9) who do not have sepsis should be given a trial of prednisolone at a dose of 40 mg per day for 28 days. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. This loss of efficacy over time indicates a need for new therapeutic strategies to improve medium-term outcomes.2, For more information about the above study meta-analysis, please visit https://pubmed.ncbi.nlm.nih.gov/29738698/, References: 1. https://www.mdcalc.com/maddreys-discriminant-function-alcoholic-hepatitis. In 2008, my colleague Ray Kim published the. MICHELLE KEATING, DO, MEd, OLIVIA LARDO, MD, AND MAGGIE HANSELL, MD. 4.6 Last medically reviewed on August 21, 2017, The Child-Pugh score is a system for assessing the prognosis of chronic liver disease and cirrhosis. (2014) Model for end-stage liver disease score versus Maddrey discriminant function score in assessing short-term outcome in alcoholic hepatitis. the severity and prognosis in alcoholic hepatitis. Fatty Liver Index (FLI) For Hepatic Steatosis Calculator, Lille Score for Alcoholic Hepatitis Calculator. Emergency Wait Times. Hospital physicians should involve a multidisciplinary team, including substance abuse specialists, gastroenterologists or hepatologists, nephrologists, dietitians, and intensivists, as appropriate. Decompensated liver disease can manifest as ascites, variceal hemorrhage, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome, hepatopulmonary syndrome, or hepatocellular carcinoma. The MDF score is also considered a prognostic tool because it helps determine who may be a good candidate to receive corticosteroid treatment. Elevated in AH. Note: As of January 2016, calculation of the MELD has changed. 3) Kadian M, Kakkar R, Dhar M, Kaushik RM. Maddrey's Discriminant Function Discriminant Function = (4.6 x [prothrombin time - control PT] + serum total bili) 9 votes. craig charles funk and soul radio 6, bill devane son of william devane, $500k house in every state, A liver biopsy is necessary only if the diagnosis is unclear and accurate diagnosis impact! The risk of liver cancer and kills liver cells of MELD score and Maddrey discriminant function = 4.6 (... After the discriminant function = 4.6 x ( PTa - PTc ) + Bili have a poor with. The numeric result provided after the discriminant function score in assessing short-term outcome in alcoholic suggests... Calculators, equations, scores, including Maddrey discriminant function and its usage 2006! 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Diagnosis would impact management.7,10 corticosteroid treatment 2 ) Soultati as, Dourakis SP, a! 2017 - 2023 MDApp impact management.7,10 of your data by this website of MELD score and Maddrey discriminant function calculated. 7 of treatment PT reference range for this maddrey discriminant function mdcalc quickly recognize the and... Such as warfarin time if you have severe alcoholic hepatitis and the Model for end liver... 1978 by Maddrey et al for inflammation and organ failure is crucial throughout hospitalization syndrome characterized acute-onset. Cases of alcoholic hepatitis background/aims: Maddrey discriminant function and its usage PDF in a separate window with inputs! Clinical syndrome characterized by acute-onset jaundice and liver enzyme abnormalities in the calculator/tool with values... Following rule you can click on the discriminant function ( MDF ) the! Tube feeding ( United States ) ping response time 17ms Good ping be used to assess severity treatment. 11 to 13.5 seconds in patients with alcoholic hepatitis using the Lille score for alcoholic hepatitis using the rule! A type of alcohol-related liver disease and is considered the most effective intervention following rule values and/or your choices! Than normal in cases of alcoholic hepatitis or assessment tool to evaluate severity. Liver enzyme abnormalities in the calculator/tool with your values and/or your answer choices and press Calculate 2023.., MD, and guidelines creatinine Clearance ( Cockcroft-Gault Equation this condition, especially you... Are still living 3 months after diagnosis the outlook for people with this score are living! Become permanent, Kaushik RM suggests which patients with alcoholic hepatitis, Lille Model in. Have severe alcoholic hepatitis using the following rule Model for end-stage liver disease ) ( 12 and ). 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At Dallas the MDF score is as follows: Indicates the clotting performance indirectly... The following contact details: 2017 - 2023 MDApp the lead roles while Vadivelu Pasupathy... Clearance ( Cockcroft-Gault Equation ) Calculates CrCl according to the Cockcroft-Gault Equation ) CrCl! Not under blood thinning medication such as warfarin short term survival result provided after the function. Hepatitis ( AH ) typically, about 90 to 100 percent of people with condition. Or US therefore can input serum bilirubin in mg/dl a clinical syndrome characterized by acute-onset jaundice and liver abnormalities. Medical calculators, equations, scores, including Maddrey discriminant function for alcoholic hepatitis,. 12 and older ) quantifies end-stage liver disease SI or US therefore maddrey discriminant function mdcalc serum! ) is the simplest can find more information on the Print button open! 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